Upstream Bio, INC Schedule 13G passive stakes

Norges Bank has reported a beneficial ownership of 7.73% in Upstream Bio, Inc., holding 4,206,586 shares as of June 30, 2026.

BlackRock, Inc. has reported beneficial ownership of 5.2% of Upstream Bio Inc.'s common stock as of June 30, 2026.

Decheng Capital Global Life Sciences Fund IV, L.P. has reported a 5% beneficial ownership stake in Upstream Bio, Inc. common stock.

TCG Crossover Fund I, L.P., TCG Crossover GP I, LLC, and Chen Yu have reported a combined beneficial ownership of 3.9% in Upstream Bio, Inc. common stock.

HBM Healthcare Investments (Cayman) Ltd. has reported a 4.1% beneficial ownership stake in Upstream Bio, Inc. as of September 30, 2025.

Norges Bank, acting on behalf of the Government of Norway, has reported a 5.3% passive ownership stake in Upstream Bio Inc.

FMR LLC and its affiliates, including Abigail P. Johnson, reported a 14.8% beneficial ownership stake in Upstream Bio Inc. common stock as of June 30, 2025.

Decheng Capital Global Life Sciences Fund IV, L.P., Decheng Capital Global Healthcare Fund (Master), LP, and related entities, along with Xiangmin Cui, have disclosed beneficial ownership of 6.1% of Upstream Bio, Inc.'s common stock as of December 31, 2024.

TCG Crossover Fund I, L.P., TCG Crossover GP I, LLC, and Chen Yu have jointly reported beneficial ownership of 5.2% of Upstream Bio, Inc.'s common stock as of December 31, 2024.

HBM Healthcare Investments (Cayman) Ltd. has reported a beneficial ownership of 5.1% in Upstream Bio, Inc., holding 2,715,056 shares of common stock as of December 31, 2024.

FMR LLC and Abigail P. Johnson have disclosed a continued beneficial ownership of 13.4% of Upstream Bio Inc.'s common stock as of December 31, 2024.