SCHEDULE: HBM Healthcare Investments Reports 4.1% Stake in Upstream Bio
Beneficial Ownership Report
HBM Healthcare Investments (Cayman) Ltd. has reported a 4.1% beneficial ownership stake in Upstream Bio, Inc. as of September 30, 2025.
Summary
- HBM Healthcare Investments (Cayman) Ltd. (the "Reporting Person") beneficially owns 2,195,111 shares of Upstream Bio, Inc. Common Stock.
- This ownership represents approximately 4.1% of Upstream Bio, Inc.'s outstanding Common Stock.
- The percentage is calculated based on 53,909,427 shares of Common Stock outstanding as of August 4, 2025.
- The Reporting Person holds sole voting power and sole dispositive power over all 2,195,111 shares.
- The board of directors of HBM Healthcare Investments (Cayman) Ltd. exercises voting and investment power over these shares.
Sentiment
Score: 5
Explanation: Neutral, as this is a factual report of beneficial ownership without performance or forward-looking statements from the issuer.
Future Outlook
NA
Industry Context
This filing indicates a significant, though non-controlling, institutional investment in Upstream Bio, a common occurrence in the biotechnology sector where specialized healthcare investment firms like HBM Healthcare Investments strategically back promising companies.
Stakeholder Impact
- Shareholders: The filing confirms a significant institutional investor holds a 4.1% stake, which can be viewed as a vote of confidence or a stable part of the shareholder base.
Key Dates
| Date | Description |
|---|---|
| 2025-08-04 | Date of shares outstanding calculation for Upstream Bio, Inc. |
| 2025-09-30 | Date of event which requires filing of this statement (beneficial ownership calculation date). |
| 2025-11-14 | Date of signature for the Schedule 13G filing. |
Keywords
HBM Healthcare Investments, Upstream Bio, Beneficial Ownership, Schedule 13G, Common Stock, Institutional Ownership, Healthcare Investments, Biotechnology
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