SCHEDULE: FMR LLC Maintains 14.8% Stake in Upstream Bio
Beneficial Ownership Report
FMR LLC and its affiliates, including Abigail P. Johnson, reported a 14.8% beneficial ownership stake in Upstream Bio Inc. common stock as of June 30, 2025.
Summary
- FMR LLC and Abigail P. Johnson collectively hold 7,936,880.31 shares of Upstream Bio Inc. common stock.
- This represents 14.8% of the total outstanding common stock of Upstream Bio Inc.
- The shares were acquired and are held in the ordinary course of business, not for the purpose of changing or influencing control of Upstream Bio Inc.
- FMR LLC is classified as a parent holding company, with subsidiaries including investment advisers and banks.
- Abigail P. Johnson serves as Director, Chairman, and Chief Executive Officer of FMR LLC and is a predominant owner of its voting shares.
Sentiment
Score: 7
Explanation: The filing indicates a significant and stable institutional ownership by FMR LLC, a major asset manager, which can be viewed positively as a vote of confidence in Upstream Bio Inc. However, as a Schedule 13G, it does not provide operational or financial performance details to assess the company's intrinsic value or future prospects.
Positives
- FMR LLC, a major institutional investor, maintains a significant 14.8% beneficial ownership in Upstream Bio Inc., signaling continued confidence in the company.
- The acquisition of shares was stated to be in the ordinary course of business, indicating a long-term investment strategy rather than an activist stance.
Negatives
- No specific negative information was disclosed in this Schedule 13G filing.
Risks
- No specific risks related to Upstream Bio Inc.'s operations or financial health were disclosed in this beneficial ownership report.
Future Outlook
This filing is a beneficial ownership report and does not contain forward-looking statements or guidance regarding Upstream Bio Inc.'s future operations or financial performance.
Management Comments
- No direct management comments from Upstream Bio Inc. were included in this beneficial ownership filing.
Industry Context
FMR LLC, a prominent global asset management firm, maintaining a significant stake in Upstream Bio Inc. indicates continued institutional interest in the biotechnology sector, particularly in companies like Upstream Bio. This type of passive investment by large funds is common across various industries.
Comparison to Industry Standards
- This filing is a beneficial ownership report and does not provide specific data points for direct comparison to industry-standard financial or operational benchmarks.
Management Changes
| Role | Previous Person | New Person | Effective Date | Reason |
|---|---|---|---|---|
Corporate Governance
| Change Type | Description | Effective Date | Impact Assessment |
|---|---|---|---|
Legal Proceedings
- No legal proceedings or regulatory matters concerning Upstream Bio Inc. were disclosed in this filing.
Related Party Transactions
- No related party transactions involving Upstream Bio Inc. were disclosed in this filing. The filing details the ownership structure of FMR LLC, noting the Johnson family's predominant ownership.
Stakeholder Impact
- Shareholders may view the continued significant institutional ownership by FMR LLC as a positive signal of long-term confidence in Upstream Bio Inc.
- No direct impact on employees, customers, suppliers, or creditors was indicated in this beneficial ownership report.
Next Steps
- No specific future actions or milestones for Upstream Bio Inc. were disclosed in this beneficial ownership filing.
Key Dates
| Date | Description |
|---|---|
| 05/23/2023 | Effective date of Power of Attorney for Richard Bourgelas, authorizing signatures on behalf of FMR LLC and Abigail P. Johnson. |
| 08/08/2023 | Date of previous Schedule 13G filing by FMR LLC (accession number: -23-002397). |
| 06/30/2025 | Date of event which requires filing of this statement, representing the snapshot date for beneficial ownership. |
| 08/05/2025 | Date the Schedule 13G Amendment No. 2 was signed and filed. |
Recommendation
holdThis Schedule 13G filing primarily reports a significant beneficial ownership stake by FMR LLC and Abigail P. Johnson in Upstream Bio Inc. While the substantial 14.8% stake by a major institutional investor signals confidence, the filing itself does not contain new financial performance data, strategic updates, or operational insights that would warrant a change in investment thesis. It confirms a stable, passive institutional holding, suggesting a 'hold' recommendation until further operational or financial disclosures are made by Upstream Bio Inc.
Keywords
Upstream Bio, FMR LLC, Abigail P. Johnson, Beneficial Ownership, Institutional Investment, Common Stock, SEC Filing, Biotechnology, Investment Management
Disclaimer:The information provided here is for general informational purposes only and does not constitute financial advice, recommendation, or endorsement of any kind. It may contain errors or omissions. You should not rely on this information to make financial decisions. Always seek the advice of a qualified financial professional before making any investment or financial decisions. Use of this information is at your own risk.