Alnylam Pharmaceuticals, INC

Market Movers (8-K)

NASDAQ
Alnylam Pharmaceuticals reported strong Q2 2026 results with significant revenue growth, but revised its full-year TTR net product revenue guidance downwards.
NASDAQ
Alnylam Pharmaceuticals announced first quarter 2026 financial results, achieving over $1 billion in quarterly product revenues for the first time, driven by significant growth in TTR therapies.
Better than expected
NASDAQ
Alnylam Pharmaceuticals' Board of Directors has granted CEO Yvonne Greenstreet a special performance-based equity award to incentivize future growth and leadership through 2029.
NASDAQ
Alnylam Pharmaceuticals reported robust fourth quarter and full year 2025 financial results, achieving GAAP and non-GAAP profitability driven by significant AMVUTTRA sales and outlining ambitious 2026 pipeline goals.
Better than expected
NASDAQ
Alnylam Pharmaceuticals announced its ambitious Alnylam 2030 strategy, alongside preliminary full-year 2025 net product revenues of $2,987 million and robust 2026 revenue guidance.
Better than expected
NASDAQ
Alnylam Pharmaceuticals announced a partial repurchase of its 1.00% Convertible Senior Notes due 2027 for approximately $51.9 million in cash.

Quarterly Earnings (10-Q)

NASDAQ
Alnylam Pharmaceuticals announced robust Q2 2026 results, driven by significant growth in AMVUTTRA sales and increased royalty revenue.
Better than expected
NASDAQ
Alnylam Pharmaceuticals announced a significant increase in total revenues, driven by strong product sales, particularly AMVUTTRA, and improved operational income.
Better than expected
NASDAQ
Alnylam Pharmaceuticals reported a significant increase in total revenues and net income for the third quarter and first nine months of 2025, driven by robust AMVUTTRA sales and a major milestone payment from Roche for zilebesiran.
Better than expected
Delay expected
Capital raise
NASDAQ
Alnylam Pharmaceuticals announced significant increases in product revenue, driven by AMVUTTRA's expanded indications, but reported a widening net loss and faced adverse rulings in key patent infringement lawsuits.
Worse than expected
Delay expected
NASDAQ
Alnylam Pharmaceuticals reports increased net product revenues and collaboration revenues in Q1 2025, driven by AMVUTTRA and strategic partnerships.
Better than expected
Delay expected
NASDAQ
Alnylam Pharmaceuticals reports a net loss for the third quarter of 2024, despite a 34% increase in net product revenues, driven by growth in AMVUTTRA sales.
Worse than expected

Annual Reports (10-K)

NASDAQ
Alnylam Pharmaceuticals reports its first profitable fiscal year in 2025, fueled by robust sales of AMVUTTRA and strategic pipeline advancements.
Better than expected
Capital raise
Delay expected
NASDAQ
Alnylam Pharmaceuticals highlights advancements in its RNAi therapeutics pipeline and commercial performance in its 2024 annual report, aiming for self-sustainability by the end of 2025.
NASDAQ
Alnylam Pharmaceuticals' 2023 10-K filing highlights its transition to a top-tier biotech company, marked by revenue growth, pipeline advancements, and strategic collaborations.
Worse than expected

Insider Trading (Form 4)

NASDAQ
Alnylam Pharmaceuticals Director David E.I. Pyott executed a series of stock transactions under a pre-arranged Rule 10b5-1(c) trading plan.
NASDAQ
Alnylam Pharmaceuticals director Benjamin Cravatt acquired stock options valued at $295.63 per share, with vesting over three years.
NASDAQ
Director Charles Elliott Sigal acquired 671 restricted stock units and 1,441 stock options as part of an annual equity incentive grant.
NASDAQ
Director Amy W. Schulman was granted 838 restricted stock units and 1,802 stock options as part of annual compensation.
NASDAQ
Director Colleen F. Reitan was granted 671 restricted stock units and 1,441 stock options as part of Alnylam Pharmaceuticals' incentive plan.
NASDAQ
Alnylam Pharmaceuticals Director David E.I. Pyott acquired 671 restricted stock units and 1,441 stock options as part of an annual equity grant.

Proxy Statements (Def-14A)

NASDAQ
Alnylam Pharmaceuticals, Inc. has announced its 2026 Annual Meeting of Stockholders will be held virtually on May 20, 2026, to elect directors, approve executive compensation, and ratify auditors.
NASDAQ
Alnylam Pharmaceuticals files an amendment to its proxy statement to clarify the voting requirements for a proposal regarding officer exculpation.
NASDAQ
Alnylam Pharmaceuticals announces its 2025 Annual Meeting of Stockholders, urging shareholders to vote on key proposals including the election of directors, approval of an amendment to the Restated Certificate of Incorporation, approval of the second amended and restated 2018 Stock Incentive Plan, an advisory vote on executive compensation, and ratification of the appointment of PricewaterhouseCoopers LLP as independent auditors.
NASDAQ
Alnylam Pharmaceuticals is set to hold its 2025 Annual Meeting of Stockholders virtually on May 8, 2025, with proposals including director elections, charter amendments, and executive compensation.
NASDAQ
Alnylam Pharmaceuticals announces its 2024 Annual Meeting of Stockholders to be held virtually on May 16, 2024, with voting open until May 15, 2024.
NASDAQ
Alnylam Pharmaceuticals announces its 2024 Annual Meeting of Stockholders to be held virtually on May 16, 2024, covering director elections, executive compensation, and auditor ratification.

Schedule 13G - Passive Investments

NASDAQ
Capital World Investors has disclosed a beneficial ownership of 10,916,799 shares, representing 8.2% of the outstanding common stock of Alnylam Pharmaceuticals, Inc.
NASDAQ
FMR LLC, through its affiliates, has reported beneficial ownership of 11.0% of Alnylam Pharmaceuticals' common stock as of March 31, 2026.
NASDAQ
Vanguard Capital Management has reported beneficial ownership of 5.35% of Alnylam Pharmaceuticals' common stock as of March 31, 2026.
NASDAQ
The Vanguard Group has reported zero beneficial ownership in Alnylam Pharmaceuticals Inc. common stock following an internal realignment on January 12, 2026.
NASDAQ
FMR LLC and its affiliates, including Abigail P. Johnson, reported a 12.8% beneficial ownership stake in Alnylam Pharmaceuticals Inc. as of September 30, 2025.
NASDAQ
The Vanguard Group has filed an amended Schedule 13G, reporting a 10.03% beneficial ownership stake in Alnylam Pharmaceuticals Inc. as of March 31, 2025.