Ms. Simantov resigned from the Board of Directors of Tempest Therapeutics, Inc. effective May 23, 2026. The resignation is not due to any disagreement with the company regarding operations, policies, or practices. A separation agreement was executed, involving the waiver of accrued and unpaid retainer fees. Existing stock option awards and capital stock ownership remain unaffected by the resignation. Indemnification rights remain in effect for six years post-separation.