SCHEDULE 13G/A: Radoff Reduces Stake in Synlogic to 4.4%

Bradley L. Radoff has amended his beneficial ownership in Synlogic, Inc., reporting a 4.4% stake as of September 30, 2025.

Summary

• Bradley L. Radoff reported beneficial ownership of 520,000 shares of Synlogic, Inc. Common Stock.
• This represents approximately 4.4% of the outstanding shares of Synlogic, Inc.
• The percentage is based on 11,698,919 shares outstanding as of August 6, 2025, as disclosed in the Issuer's Form S-3.
• The filing is an Amendment No. 1 to a Schedule 13G, indicating a change from a previous filing.
• Mr. Radoff holds sole voting and sole dispositive power over all 520,000 shares.
• The securities were not acquired or held for the purpose of changing or influencing control of the issuer, other than activities solely in connection with a nomination under Rule 14a-11.

Sentiment

Score: 4

Explanation: The filing itself is a factual disclosure, but the information conveyed (a reduction in a significant investor's stake below the 5% threshold) could be interpreted negatively by the market.

Positives

• NA

Negatives

• The filing indicates a reduction in Bradley L. Radoff's beneficial ownership to below 5%, suggesting a decrease in a significant investor's stake in Synlogic, Inc.

Risks

• NA

Future Outlook

NA

Industry Context

NA

Stakeholder Impact

• Shareholders may view the reduction in a significant investor's stake as a negative signal, potentially impacting investor confidence and share price.

Key Dates

Recommendation

The filing indicates a reduction in a significant investor's stake below the 5% threshold, which is generally a negative signal. However, without further context on Synlogic's operational performance or other market factors, a 'hold' recommendation is prudent for existing investors to assess further developments, while new investors might exercise caution.

Keywords

Synlogic Inc, SYNLOGIC, Bradley L. Radoff, Schedule 13G, Beneficial Ownership, Common Stock, Shareholder, Investment