SCHEDULE: State Street Discloses 5.1% Stake in Twist Bioscience

State Street Corporation has reported a 5.1% beneficial ownership stake in Twist Bioscience Corp. as of September 30, 2025.

Summary

• State Street Corporation beneficially owns 3,089,063 shares of Twist Bioscience Corp. common stock.
• This ownership represents 5.1% of the class of securities.
• State Street Corporation holds shared voting power over 2,882,170 shares and shared dispositive power over 3,089,063 shares.
• The filing is made under Rule 13d-1(b), indicating a passive investment intent.
• The securities were acquired and are held in the ordinary course of business, not for the purpose of changing or influencing control of the issuer.
• Several State Street Global Advisors entities are identified as subsidiaries involved in the acquisition of these securities.

Sentiment

Score: 6

Explanation: The filing indicates a significant institutional stake, which is generally a neutral to slightly positive signal for the issuer, as it reflects a major financial institution's investment. However, it provides no operational or financial performance details.

Positives

• Increased institutional ownership by a major financial institution like State Street Corporation can be viewed positively by the market, signaling confidence in Twist Bioscience Corp.

Negatives

• No specific negative information regarding Twist Bioscience Corp. is disclosed in this ownership filing.

Risks

• This filing does not contain specific risk factors related to Twist Bioscience Corp.'s operations or financial health.

Future Outlook

This filing is a disclosure of current beneficial ownership and does not provide forward-looking statements or guidance regarding Twist Bioscience Corp.'s future performance or State Street Corporation's investment strategy beyond its passive intent.

Industry Context

Schedule 13G filings are standard disclosures by institutional investors who acquire more than 5% of a company's stock with a passive investment intent. State Street Corporation, as a major asset manager, frequently files such disclosures across numerous public companies, reflecting its role in managing various funds and portfolios.

Stakeholder Impact

• Shareholders: Provides transparency regarding significant institutional ownership, potentially reinforcing confidence in the stock due to a major investor's stake.
• Management: Awareness of a large, passive institutional holder, though without direct influence on control.

Key Dates

Keywords

Twist Bioscience, State Street Corporation, Beneficial Ownership, Institutional Investor, Common Stock, SEC Filing, Schedule 13G, Biotechnology