SCHEDULE: Opaleye Management Discloses Sol-Gel Technologies Stake

Opaleye Management Inc., Opaleye L.P., and James Silverman have jointly filed a Schedule 13G, reporting beneficial ownership of 15.41% of Sol-Gel Technologies Ltd. ordinary shares as of March 31, 2026.

Summary

• Opaleye Management Inc., acting as the investment adviser, along with Opaleye L.P. (the Fund) and James Silverman, have collectively disclosed their beneficial ownership of Sol-Gel Technologies Ltd. ordinary shares.
• As of March 31, 2026, the reporting persons collectively beneficially own 500,000 ordinary shares, representing 15.41% of the class.
• Opaleye, L.P. directly holds 485,000 shares, representing 14.94% of the class.
• James Silverman exercises control over Opaleye Management Inc., which advises the Fund.
• The filing is made under Schedule 13G, indicating the reporting persons are not seeking to influence or change control of the issuer.

Sentiment

Score: 5

Explanation: StockSavvy.ai views this as a neutral filing, as it is a standard disclosure of beneficial ownership by investment entities and does not provide operational or financial performance updates for the company.

Positives

• Significant ownership stake of 15.41% in Sol-Gel Technologies Ltd. by Opaleye entities and James Silverman.
• Clear disclosure of beneficial ownership and reporting structure.

Risks

• The filing does not detail specific risks associated with Sol-Gel Technologies Ltd. itself, but rather reports ownership. Any risks would be inherent to the company's operations and market position, which are not elaborated upon in this filing.

Future Outlook

The filing does not contain forward-looking statements or guidance from Sol-Gel Technologies Ltd. It is a disclosure of beneficial ownership.

Management Comments

• "The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein."
• "By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11."

Industry Context

StockSavvy.ai notes that Schedule 13G filings are common for institutional investors and investment managers who acquire significant stakes in public companies but do not intend to control or influence the company's management. This filing indicates a substantial passive investment by Opaleye entities in Sol-Gel Technologies Ltd.

Stakeholder Impact

• Shareholders: The disclosure provides transparency regarding a significant ownership block, which may be of interest to other shareholders.
• Management of Sol-Gel Technologies Ltd.: The filing confirms that the reporting persons are passive investors and do not intend to influence control, which may provide reassurance to current management.

Next Steps

• The reporting persons will continue to file amendments to Schedule 13G as required by SEC regulations if their beneficial ownership changes.

Key Dates

Keywords

Sol-Gel Technologies Ltd, Schedule 13G, Opaleye Management Inc., Opaleye L.P., James Silverman, Beneficial Ownership, Ordinary Shares, SEC Filing, Investment Adviser