SCHEDULE 13G/A: Third Rock Ventures Entities Disclose Significant Stakes in Septerna, Inc. Common Stock

Third Rock Ventures V, L.P. and Third Rock Ventures VI, L.P., along with their respective general partners, have filed an amended Schedule 13G disclosing beneficial ownership of 14.0% and 9.5% respectively, in Septerna, Inc.'s common stock.

Summary

• Third Rock Ventures V, L.P. (TRV V) and its related entities beneficially own 6,215,591 shares of Septerna, Inc. Common Stock.
• This ownership by TRV V and its related entities represents approximately 14.0% of the outstanding shares of Septerna, Inc.
• Third Rock Ventures VI, L.P. (TRV VI) and its related entities beneficially own 4,211,659 shares of Septerna, Inc. Common Stock.
• This ownership by TRV VI and its related entities represents approximately 9.5% of the outstanding shares of Septerna, Inc.
• The percentages of class were calculated based on 44,442,496 shares of common stock issued and outstanding as of March 17, 2025, as disclosed in Septerna, Inc.'s 10-K filed on March 27, 2025.
• All reporting persons (TRV V, TRV GP V, TRV GP V LLC, TRV VI, TRV GP VI, TRV GP VI LLC) hold shared voting and shared dispositive power over their respective beneficially owned shares.
• The reporting persons disclaim the existence of a 'group' for purposes of Rule 13d-5 of the Securities Exchange Act of 1934.

Sentiment

Score: 5

Explanation: A Schedule 13G filing is a factual disclosure of ownership and does not inherently convey positive or negative sentiment regarding the company's performance or outlook.

Future Outlook

This document does not contain any forward-looking statements or guidance.

Industry Context

This filing indicates continued significant investment by a venture capital firm, Third Rock Ventures, in Septerna, Inc., a biotechnology or pharmaceutical company, which is common in the life sciences sector where venture capital plays a crucial role in funding early-stage and growth companies.

Stakeholder Impact

• Shareholders: Provides transparency regarding significant institutional ownership, which can influence market perception and liquidity.
• Investors: Offers insight into the holdings of a prominent venture capital firm, potentially signaling confidence in the company's long-term prospects.

Key Dates

Keywords

Septerna Inc, Third Rock Ventures, Beneficial Ownership, Schedule 13G, SEC Filing, Common Stock, Institutional Investor, Venture Capital