SCHEDULE 13G/A: Driehaus Capital Management Boosts Stake in Septerna, Inc. to Over 10%

Driehaus Capital Management LLC has increased its beneficial ownership in Septerna, Inc. to 10.46% as of May 31, 2025, up from 7.03% reported on March 31, 2025.

Summary

• Driehaus Capital Management LLC (DCM) filed an Amendment No. 2 to Schedule 13G regarding its beneficial ownership in Septerna, Inc. (SEPN).
• As of May 31, 2025, DCM beneficially owned 4,659,911 shares of Septerna, Inc. Common Stock.
• This represents 10.46% of the class of Septerna, Inc. Common Stock.
• This ownership percentage is an increase from the 7.03% reported by DCM as of March 31, 2025.
• DCM holds shared voting power and shared dispositive power over all 4,659,911 shares.
• The shares are held by numerous clients on a fully discretionary basis in accounts managed by DCM.
• DCM certifies that the securities were acquired and are held in the ordinary course of business and not for the purpose of changing or influencing control of the issuer.

Sentiment

Score: 7

Explanation: The increased stake by a reputable investment firm suggests a positive outlook on the company, indicating confidence in its value or future performance. This is generally a bullish signal for the stock.

Positives

• Driehaus Capital Management LLC, a significant institutional investor, increased its stake in Septerna, Inc. from 7.03% to 10.46%, indicating increased confidence or a positive outlook on the company's prospects.
• The acquisition of shares is stated to be in the ordinary course of business, suggesting a strategic investment rather than an attempt to influence control.

Future Outlook

NA

Industry Context

This filing indicates an institutional investor's increased conviction in Septerna, Inc., a biotechnology or pharmaceutical company (implied by 'South San Francisco' address and 'Common Stock' in a biotech-heavy region). Such an increase in stake by a prominent asset manager like Driehaus Capital Management can be seen as a positive signal within the industry, potentially attracting further investor interest.

Stakeholder Impact

• Shareholders: The increased institutional ownership may be perceived positively, potentially boosting investor confidence and attracting more capital, which could positively impact share price.
• Company Management: Increased institutional ownership could lead to greater scrutiny and engagement from the investor, potentially influencing strategic decisions or corporate governance.

Key Dates

Keywords

Septerna Inc., Driehaus Capital Management, SEC Filing, Schedule 13G, Beneficial Ownership, Common Stock, Institutional Investment, Ownership Increase, SEPN