SCHEDULE: Opaleye Management Reports 6.58% Stake in Rezolute Inc.

Opaleye Management Inc., Opaleye L.P., and James Silverman have jointly filed a Schedule 13G, disclosing a combined beneficial ownership of 6.58% of Rezolute, Inc.'s common stock as of March 31, 2026.

Summary

• Opaleye Management Inc., Opaleye L.P., and James Silverman have filed a joint Schedule 13G, reporting beneficial ownership of Rezolute, Inc. common stock.
• The filing indicates a total of 6,300,000 shares are beneficially owned, representing 6.58% of the class.
• This ownership is based on 95,697,685 common shares outstanding as of February 9, 2026, as reported by Rezolute, Inc. in its Form 10-Q.
• Opaleye Management Inc. acts as the investment adviser, holding shared voting and dispositive power over shares in a managed account.
• Opaleye L.P. is the fund holding the shares, and James Silverman is identified as the controlling person of the Adviser.

Sentiment

Score: 5

Explanation: StockSavvy.ai views this as a neutral filing. It reports a significant ownership stake but provides no new financial or strategic information about Rezolute, Inc. itself, nor does it indicate any immediate intent to influence control.

Positives

• Significant stake reported by a professional investment entity, potentially indicating confidence in the company's future.
• The filing is current as of March 31, 2026, providing up-to-date ownership information.

Negatives

• The filing does not contain financial performance data or strategic updates from Rezolute, Inc. itself, only ownership information.
• The reporting persons state that the filing should not be construed as an admission of beneficial ownership for purposes of changing or influencing control.

Risks

• Potential for future changes in beneficial ownership, which could impact share price.
• The reporting persons' disclaimer regarding control suggests their current stake may not be intended for activist purposes, but this could change.

Future Outlook

The filing itself does not contain forward-looking statements or guidance from Rezolute, Inc. It pertains solely to the ownership stake of the reporting persons.

Management Comments

• "The filing of this statement should not be construed as an admission that any of the Reporting Persons is, for purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of any of the shares reported herein."
• "Includes shares held in a managed account over which the Adviser has shared voting and dispositive power."
• "This Joint Filing Agreement may be terminated by any of the Filers upon written notice or such lesser period of notice as the Filers may mutually agree."

Industry Context

StockSavvy.ai notes that Schedule 13G filings are common for institutional investors and significant shareholders to report stakes exceeding 5% in a public company. This filing indicates a substantial, but not controlling, ownership position by Opaleye entities in Rezolute, Inc.

Stakeholder Impact

• Shareholders: The filing provides transparency on a significant ownership block, which could be of interest to other investors.
• Management of Rezolute, Inc.: Awareness of substantial ownership by investment entities is a standard consideration for corporate governance.

Next Steps

• The reporting persons may amend this filing if their beneficial ownership changes.
• Rezolute, Inc. may continue its business operations as disclosed in its other filings.

Key Dates

Keywords

Schedule 13G, Rezolute Inc., Opaleye Management Inc., Opaleye L.P., James Silverman, Beneficial Ownership, Common Stock, SEC Filing, Investment Adviser, Managed Account