SCHEDULE: Opaleye Management Discloses 5.3% Stake in Rezolute

Opaleye Management Inc., along with Opaleye, L.P. and James Silverman, has disclosed a beneficial ownership of 5.3% of Rezolute, Inc.'s common stock.

Summary

• Opaleye Management Inc., Opaleye, L.P., and James Silverman have filed a Schedule 13G, disclosing their beneficial ownership in Rezolute, Inc.
• Opaleye Management Inc. and James Silverman collectively beneficially own 4,912,900 shares of Rezolute, Inc. common stock.
• This represents 5.30% of Rezolute, Inc.'s common stock, based on 92,727,532 shares outstanding as of November 4, 2025.
• Opaleye, L.P. separately beneficially owns 4,785,000 shares, representing 5.16% of the class.
• The shares were acquired and are held in the ordinary course of business, not for the purpose of changing or influencing control of the issuer.

Sentiment

Score: 6

Explanation: The disclosure of a significant beneficial ownership stake by an institutional investor like Opaleye Management Inc. can be viewed as a vote of confidence in Rezolute, Inc., even if the filing explicitly states no intent to influence control.

Positives

• A significant institutional investor, Opaleye Management Inc., has taken a substantial stake in Rezolute, Inc., indicating potential confidence in the company's long-term prospects.
• The filing explicitly states the acquisition is for ordinary course of business, not for control, which may suggest a passive, long-term investment strategy.

Risks

• The filing does not detail specific risks related to Rezolute, Inc.'s operations. It only states the reporting persons are not seeking to influence control, which mitigates the risk of activist investor actions.

Future Outlook

This filing does not provide any forward-looking statements or guidance regarding Rezolute, Inc.'s future outlook.

Management Comments

• The securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under §§ 240.14a-11.

Industry Context

This Schedule 13G filing is a standard disclosure of beneficial ownership by an institutional investor and does not provide specific insights into broader industry trends or competitive landscape for Rezolute, Inc.

Comparison to Industry Standards

• NA

Stakeholder Impact

• Shareholders: The disclosure of a significant institutional stake may positively influence investor sentiment and potentially the stock price, signaling institutional confidence.

Next Steps

• The filing does not outline any specific future actions, events, or milestones for Rezolute, Inc. or the reporting persons beyond the ongoing ownership.

Key Dates

Keywords

Rezolute Inc., Opaleye Management Inc., Opaleye L.P., James Silverman, Schedule 13G, Beneficial Ownership, Common Stock, RZLT, Institutional Investor, Equity Stake