SCHEDULE: OPKO Health: Frost Group Amends Schedule 13D Filing

Phillip Frost, M.D. and associated entities have amended their Schedule 13D filing for OPKO Health, Inc., reporting a combined beneficial ownership of approximately 34.1% of the company's outstanding common stock.

Summary

• This filing is an amendment (Amendment No. 28) to a Schedule 13D, originally filed on February 15, 2007, concerning the common stock of OPKO Health, Inc.
• The amendment is primarily due to a change in the Issuer's number of outstanding shares of Common Stock.
• As of June 29, 2026, OPKO Health, Inc. had 746,328,225 shares of Common Stock outstanding.
• The reporting persons include Phillip Frost, M.D. ('Dr. Frost'), Frost Gamma Investments Trust ('Gamma Trust'), and Frost Nevada Investments Trust ('Frost Nevada').
• Gamma Trust directly beneficially owns 216,706,448 shares (29.0% of outstanding).
• Frost Nevada directly beneficially owns 30,127,177 shares (4.0% of outstanding).
• Dr. Frost individually owns 3,068,951 shares, holds options for 2,425,000 shares exercisable within 60 days, and has 250,000 restricted stock units vesting within 60 days.
• The Phillip and Patricia Frost Philanthropic Foundation, Inc. owns 2,851,830 shares.
• The aggregate beneficial ownership reported for Dr. Frost is 255,429,406 shares, representing approximately 34.1% of the Issuer's outstanding shares.
• This aggregate figure includes shares held individually, by trusts controlled by Dr. Frost, options, and certain restricted stock units.
• Dr. Frost's ownership excludes restricted stock units that will not begin to vest until July 2027.
• No transactions in the Common Stock were effected by Gamma Trust, Frost Nevada, or Dr. Frost in the last 60 days prior to the filing.

Sentiment

Score: 5

Explanation: StockSavvy.ai views this filing as neutral, as it is an administrative update regarding ownership percentages due to changes in outstanding shares, rather than a report on operational performance or strategic shifts.

Positives

• Dr. Phillip Frost and associated entities maintain a significant controlling stake in OPKO Health, Inc., with a combined beneficial ownership of approximately 34.1% of the outstanding common stock.
• The filing indicates that Dr. Frost has sole voting and dispositive power over a substantial portion of these shares, including those held by trusts he controls.
• Options and restricted stock units exercisable or vesting within 60 days suggest potential for increased ownership or influence in the near term.

Negatives

• The filing is an amendment primarily triggered by a change in the number of outstanding shares, which could indicate ongoing share dilution or issuance activities by the company.
• The significant concentration of ownership by a single individual and associated entities could limit the free float and potentially impact stock liquidity.

Risks

• The filing does not explicitly detail risks, but the nature of a Schedule 13D filing implies a significant stake that could be subject to market fluctuations and regulatory scrutiny.
• The exclusion of certain restricted stock units from the reported ownership, which vest later, indicates potential future changes in beneficial ownership that are not immediately reflected.

Future Outlook

The filing does not contain forward-looking statements or guidance. It primarily reports on current beneficial ownership and is triggered by a change in the number of outstanding shares.

Industry Context

StockSavvy.ai notes that significant ownership filings like this Schedule 13D amendment are common in the healthcare and biotechnology sectors, often reflecting the influence of founders or major investment groups. The healthcare industry is characterized by substantial capital requirements and evolving regulatory landscapes, making concentrated ownership a frequent feature.

Stakeholder Impact

• Shareholders: The filing confirms a significant controlling stake, which may influence corporate decisions and strategic direction. Changes in share count could impact per-share metrics.
• Management: The substantial ownership by Dr. Frost and associated entities reinforces his significant influence over the company's governance and strategic planning.
• Creditors/Suppliers: No direct impact indicated, but the company's financial health, influenced by its major shareholder, remains a factor.

Next Steps

• Continued monitoring of OPKO Health, Inc.'s share count and any further amendments to Schedule 13D filings.
• Observation of the vesting of restricted stock units and options within the next 60 days.

Key Dates

Keywords

OPKO Health, Schedule 13D, Phillip Frost, Gamma Trust, Frost Nevada, Beneficial Ownership, Common Stock, SEC Filing, Amendment, Shareholder