SCHEDULE: Exact Sciences Boosts MDxHealth Stake to 12%

Exact Sciences Corporation and its subsidiary, Genomic Health, Inc., have reported a 12.0% beneficial ownership stake in MDxHealth SA ordinary shares.

Summary

• Genomic Health, Inc. and its parent company, Exact Sciences Corporation, collectively beneficially own 6,441,171 ordinary shares of MDxHealth SA.
• This ownership represents 12.0% of MDxHealth SA's total ordinary shares outstanding.
• The beneficial ownership includes 2,441,171 directly owned ordinary shares and warrants/contractual rights to purchase an additional 4,000,000 ordinary shares held by Genomic Health, Inc.
• The percentage of class is calculated based on 49,497,334 ordinary shares issued and outstanding, as detailed in MDxHealth SA's Registration Statement on Form F-3 filed on December 29, 2025.
• The securities were not acquired and are not held for the purpose of changing or influencing the control of MDxHealth SA.

Sentiment

Score: 6

Explanation: The filing is a routine disclosure of significant beneficial ownership by a major industry player. While not an operational update, the increased institutional interest from Exact Sciences Corporation can be viewed as a moderately positive signal for MDxHealth SA, implying confidence from a strategic investor.

Positives

• Increased institutional ownership by Exact Sciences Corporation, a significant player in the diagnostics industry, signals potential confidence in MDxHealth SA's long-term prospects.

Future Outlook

NA

Industry Context

Exact Sciences Corporation, a prominent company in cancer diagnostics, increasing its stake in MDxHealth SA, also a diagnostics company, suggests a potential strategic alignment or a vote of confidence in MDxHealth's market position or technology within the broader diagnostics industry.

Related Party Transactions

• Genomic Health, Inc. is a wholly-owned subsidiary of Exact Sciences Corporation, and their beneficial ownership of MDxHealth SA shares is reported jointly, reflecting their corporate relationship.

Stakeholder Impact

• Shareholders: The disclosure of increased institutional ownership by a significant industry player like Exact Sciences Corporation could positively influence investor sentiment and perception of MDxHealth SA's value and future prospects.

Key Dates

Recommendation

The filing indicates a significant beneficial ownership stake by Exact Sciences Corporation, a major player in the diagnostics industry, in MDxHealth SA. While this signals confidence from a strategic investor, the Schedule 13G itself does not provide operational or financial performance details of MDxHealth SA to warrant a stronger buy or sell recommendation. Investors should consider this increased institutional interest as a potentially positive long-term signal but should seek further financial and operational data before making definitive investment decisions.

Keywords

MDxHealth SA, Exact Sciences Corporation, Genomic Health Inc, Schedule 13G, Beneficial Ownership, Ordinary Shares, Biotechnology, Diagnostics, SEC Filing, Institutional Ownership