SCHEDULE: FMR LLC Amends Inspire Medical Systems Stake

FMR LLC and Abigail P. Johnson reported an aggregate beneficial ownership of 2.5% of Inspire Medical Systems Inc. common stock in an amended Schedule 13G filing.

Summary

• FMR LLC and Abigail P. Johnson filed an Amendment No. 4 to Schedule 13G regarding their beneficial ownership in Inspire Medical Systems Inc.
• As of September 30, 2025, the reporting persons beneficially own an aggregate of 741,312.10 shares of common stock.
• This represents 2.5% of the total outstanding common stock of Inspire Medical Systems Inc.
• FMR LLC holds sole voting power over 739,599.00 shares and sole dispositive power over 741,312.10 shares.
• Abigail P. Johnson, as a Director, Chairman, and CEO of FMR LLC, is also deemed to beneficially own 741,312.10 shares with sole dispositive power.
• The filing indicates that FMR LLC, through its subsidiaries, acts as an investment adviser and a parent holding company.
• No other single person's interest in the common stock exceeds five percent of the total outstanding shares.

Sentiment

Score: 5

Explanation: The filing is a routine amendment to a Schedule 13G, reporting a beneficial ownership stake of 2.5% by FMR LLC and Abigail P. Johnson. It does not contain performance data or strategic updates that would significantly alter sentiment. The continued holding by a large institutional investor is a neutral to slightly positive signal.

Positives

• A significant institutional investor, FMR LLC, maintains a 2.5% beneficial ownership stake in Inspire Medical Systems Inc., indicating continued investment interest.

Negatives

• NA (The filing is a disclosure of beneficial ownership and does not contain information on company performance or operational negatives.)

Risks

• NA (The filing is a disclosure of beneficial ownership and does not contain information on company-specific risks.)

Future Outlook

NA (The filing is a disclosure of beneficial ownership and does not contain forward-looking statements or guidance.)

Management Comments

• NA (The filing contains signatures for the filing itself, not comments on company operations or strategy.)

Industry Context

This filing reflects a routine disclosure of beneficial ownership by a major asset manager, FMR LLC, in a publicly traded medical device company, Inspire Medical Systems Inc. It does not provide specific insights into broader industry trends or competitive positioning beyond confirming FMR LLC's continued investment in the sector.

Comparison to Industry Standards

• NA (This filing is a disclosure of beneficial ownership and does not provide data for comparison to industry benchmarks or specific comparable companies/projects.)

Stakeholder Impact

• Shareholders: Provides transparency regarding a significant institutional investor's stake in the company.

Next Steps

• NA (The filing does not outline future actions, events, or milestones for Inspire Medical Systems Inc.)

Key Dates

Keywords

Inspire Medical Systems Inc, FMR LLC, Abigail P. Johnson, Schedule 13G, Beneficial Ownership, Common Stock, Institutional Investor, SEC Filing