SCHEDULE: FMR LLC Discloses 9.9% Stake in Day One Biopharma

Sentiment:

Beneficial Ownership Report (Schedule 13G Amendment)


FMR LLC and Abigail P. Johnson have filed an amended Schedule 13G, reporting a 9.9% beneficial ownership stake in Day One Biopharmaceuticals Inc. as of September 30, 2025.

Summary

  • FMR LLC and Abigail P. Johnson reported beneficial ownership of 10,097,668.36 shares of common stock in DAY ONE BIOPHARMACEUTICALS INC.
  • This represents 9.9% of the company's outstanding common stock.
  • The filing is an Amendment No. 4 to a previous Schedule 13G, indicating an update to their reported ownership.
  • The ownership is reported as of September 30, 2025.
  • FMR LLC holds sole voting power over 10,083,983.00 shares and sole dispositive power over 10,097,668.36 shares.
  • Abigail P. Johnson, as a Director, Chairman, and Chief Executive Officer of FMR LLC and a predominant owner of its voting shares, is deemed to beneficially own the same aggregate amount of shares.
  • The securities were acquired and are held in the ordinary course of business and not for the purpose of changing or influencing control of the issuer.
  • Several FMR LLC subsidiaries, including Fidelity Management & Research Company LLC, are identified as entities beneficially owning shares, with Fidelity Management & Research Company LLC owning 5% or greater of the outstanding shares.

Sentiment

Score: 5

Explanation: Neutral, as this is a factual disclosure of beneficial ownership and does not contain performance or forward-looking statements from the issuer.

Future Outlook

This filing does not provide any forward-looking statements or guidance from Day One Biopharmaceuticals Inc.

Industry Context

This filing indicates continued significant institutional interest in Day One Biopharmaceuticals Inc. by a major asset manager, FMR LLC (Fidelity). Such substantial ownership by a prominent investment firm can signal confidence in the company's long-term prospects within the biotechnology and pharmaceutical sector.

Stakeholder Impact

  • Shareholders: Provides transparency regarding significant institutional ownership, which can influence market perception and liquidity.
  • Company Management: Awareness of a large, stable institutional shareholder can impact strategic decisions and investor relations.

Key Dates

DateDescription
2023-01-03Effective date of Power of Attorney for FMR LLC.
2023-01-10Date of Schedule 13G filing by FMR LLC where Power of Attorney is incorporated by reference.
2023-01-26Effective date of Power of Attorney for Abigail P. Johnson.
2023-01-31Date of Schedule 13G filing by FMR LLC where Abigail P. Johnson's Power of Attorney is incorporated by reference.
2025-09-30Date of event which requires filing of this statement (reporting period end date for beneficial ownership).
2025-11-04Signature date of the Schedule 13G filing.

Keywords

Day One Biopharmaceuticals, FMR LLC, Abigail P. Johnson, Schedule 13G, Beneficial Ownership, Common Stock, Institutional Investor, Biotechnology, Pharmaceuticals, Investment Management

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