S-1/A: Aytu BioPharma Files Amended S-1 Registration Statement, Adjusts Offering Fees and Delays Effectiveness
Amendment to Registration Statement
Aytu BioPharma, Inc. filed an Amendment No. 1 to its S-1 Registration Statement, primarily to update the filing fee table for a proposed offering of common stock and prefunded warrants, and to delay the effective date.
Summary
- This document is Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333-287728) filed by Aytu BioPharma, Inc. on June 5, 2025.
- The amendment is an 'exhibits-only filing' specifically to amend Exhibit 107, which details the Calculation of Filing Fee Table.
- The prospectus from the original S-1 filing remains unchanged and has been omitted from this amendment.
- The proposed maximum aggregate offering price for the securities, including Common Stock and Prefunded Warrants, is $13,800,000.
- The registration fee for this offering is calculated at $2,112.78, based on a fee rate of 0.00015310.
- Aytu BioPharma previously paid $1,837.20 for a transaction with a total offering amount of $12,000,000, resulting in a net fee due of $275.58.
- The registration statement also covers any additional shares issuable due to share splits, share dividends, recapitalizations, or similar transactions, as per Rule 416.
- The proposed maximum aggregate offering price of Common Stock will be reduced on a dollar-for-dollar basis based on the offering price of any prefunded warrants issued, and vice-versa.
Sentiment
Score: 5
Explanation: The document is a procedural amendment to a registration statement, primarily updating filing fees and delaying the effective date. It contains no new operational or financial performance data, thus maintaining a neutral sentiment.
Positives
- The company is actively pursuing a capital raise, indicating efforts to secure funding for its operations or strategic initiatives.
Negatives
- The effective date of the registration statement is being delayed, which introduces uncertainty regarding the timing of the proposed capital raise.
Risks
- Potential dilution for existing shareholders due to the proposed offering of common stock and prefunded warrants.
- Uncertainty surrounding the effective date of the registration statement could impact the company's ability to access capital in a timely manner.
Future Outlook
The proposed sale to the public is expected to commence as soon as practicable after the effective date of this registration statement. However, the effective date is currently delayed until the registrant files a further amendment or the Commission determines its effectiveness.
Management Comments
- "The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date as the Commission acting pursuant to said Section 8(a), may determine."
Industry Context
As a biopharmaceutical company, Aytu BioPharma's capital raising efforts are typical for the industry, which often requires significant funding for research, development, and commercialization of products. The use of common stock and prefunded warrants is a common financing mechanism in the biotech sector to raise capital while managing immediate dilution.
Management Changes
| Role | Previous Person | New Person | Effective Date | Reason |
|---|---|---|---|---|
| Chief Executive Officer | NA | Joshua R. Disbrow | February 13, 2023 | Amended and Restated Employment Agreement |
| Chief Financial Officer | NA | Ryan J. Selhorn | November 11, 2024 | Amended and Restated Employment Agreement |
| Former Executive | Mark K. Oki | NA | December 1, 2024 | Separation and Release Agreement |
| Chief Executive Officer and Director (Principal Executive Officer) | NA | Joshua R. Disbrow | June 5, 2025 | Signed registration statement |
| Chief Financial Officer (Principal Financial and Accounting Officer) | NA | Ryan J. Selhorn | June 5, 2025 | Signed registration statement |
| Chairman | NA | John A. Donofrio, Jr. | June 5, 2025 | Signed registration statement |
| Director | NA | Carl C. Dockery | June 5, 2025 | Signed registration statement |
| Director | NA | Abhinav Jain | June 5, 2025 | Signed registration statement |
| Director | NA | Vivian Liu | June 5, 2025 | Signed registration statement |
Corporate Governance
| Change Type | Description | Effective Date | Impact Assessment |
|---|---|---|---|
| Bylaws Amendment | Amended and Restated Bylaws adopted. | May 9, 2022 | Standard update to corporate governance framework, potentially affecting internal operational procedures or shareholder rights. |
| Equity Incentive Plan Amendment | Amendment to the Aytu BioPharma, Inc. 2023 Equity Incentive Plan. | May 21, 2025 | Likely adjusts terms for equity compensation, potentially impacting future dilution or incentive structures for employees and management. |
| Indemnification Agreement | Form of Indemnification Agreement filed. | July 1, 2022 | Provides protection to directors and officers, which is a common corporate governance practice to attract and retain qualified personnel. |
| Certificate of Incorporation Amendments | Multiple amendments to the Certificate of Incorporation over various dates. | Various (e.g., June 3, 2015, June 1, 2016, June 30, 2016, August 25, 2017, August 10, 2018, December 8, 2020, May 20, 2020, March 22, 2021, January 4, 2023) | Reflects changes to the company's fundamental corporate structure, such as authorized shares, name changes, or other charter provisions, which can impact shareholder rights or future capital raising flexibility. |
Related Party Transactions
- Amended and Restated Employment Agreement with Joshua R. Disbrow (Chief Executive Officer) dated February 13, 2023.
- Amended and Restated Employment Agreement with Jarrett T. Disbrow dated March 20, 2023.
- Amended and Restated Employment Agreement with Greg Pyszczymuka dated March 21, 2023.
- Amended and Restated Employment Agreement with Ryan J. Selhorn (Chief Financial Officer) dated November 11, 2024.
- Separation and Release Agreement with Mark K. Oki dated December 1, 2024.
Stakeholder Impact
- Shareholders: Potential for dilution from the proposed offering of common stock and warrants. The delay in the effective date introduces uncertainty regarding the timing of the capital raise.
- Management/Employees: Employment agreements and equity incentive plans are in place, indicating ongoing compensation and retention strategies.
Next Steps
- The registrant must file a further amendment specifically stating that the registration statement shall become effective.
- The Securities and Exchange Commission (SEC) may determine the effective date of the registration statement.
- The proposed sale to the public will commence as soon as practicable after the registration statement becomes effective.
Key Dates
| Date | Description |
|---|---|
| June 3, 2015 | Certificate of Incorporation effective. |
| June 9, 2015 | 8-K filing for Certificate of Incorporation. |
| June 1, 2016 | Certificate of Amendment of Certificate of Incorporation effective. |
| June 2, 2016 | 8-K filing for Certificate of Amendment of Certificate of Incorporation. |
| June 30, 2016 | Certificate of Amendment of Certificate of Incorporation effective. |
| July 1, 2016 | 8-K filing for Certificate of Amendment of Certificate of Incorporation. |
| July 26, 2017 | 2015 Stock Option and Incentive Plan amended. |
| July 27, 2017 | 8-K filing for 2015 Stock Option and Incentive Plan. |
| August 25, 2017 | Certificate of Amendment of Certificate of Incorporation effective. |
| August 29, 2017 | 8-K filing for Certificate of Amendment of Certificate of Incorporation. |
| February 27, 2018 | S-1 filing for Form of Common Stock Purchase Warrant. |
| June 11, 2018 | Amended and Restated Exclusive License Agreement with Magna Pharmaceuticals, Inc. |
| August 10, 2018 | Certificate of Amendment to the Restated Certificate of Incorporation effective. |
| August 10, 2018 | 8-K filing for Certificate of Amendment to the Restated Certificate of Incorporation. |
| September 6, 2018 | 10-K filing for Amended and Restated Exclusive License Agreement. |
| November 2, 2018 | License, Development, Manufacturing and Supply Agreement. |
| February 7, 2019 | 10-Q filing for Common Stock Purchase Warrant and License, Development, Manufacturing and Supply Agreement. |
| September 12, 2019 | Agreement and Plan of Merger with Innovus Pharmaceuticals, Inc. |
| September 18, 2019 | 8-K filing for Agreement and Plan of Merger and Form of Contingent Value Rights Agreement. |
| October 2, 2019 | Loan and Security Agreement with Encina Business Credit, LLC. |
| October 3, 2019 | 8-K filing for Loan and Security Agreement. |
| October 10, 2019 | Asset Purchase Agreement with Cerecor Inc. |
| October 15, 2019 | 8-K filing for Asset Purchase Agreement. |
| November 1, 2019 | First Amendment to Asset Purchase Agreement with Cerecor, Inc. |
| November 4, 2019 | 8-K filing for First Amendment to Asset Purchase Agreement. |
| November 29, 2019 | Waiver and Amendment to the July 29, 2019 Amended and Restated License and Supply Agreement. |
| December 2, 2019 | 8-K filing for Waiver and Amendment. |
| December 20, 2019 | Exclusive License Agreement with Johns Hopkins University. |
| December 21, 2019 | Option Agreement with Denovo Biopharma LLC. |
| March 13, 2020 | 8-K filing for Form of Placement Agent Common Stock Purchase Warrant and Form of Common Stock Purchase Warrant. |
| March 20, 2020 | 8-K filing for Form of Common Stock Purchase Warrant and Form of Placement Agent Common Stock Purchase Warrant. |
| May 20, 2020 | Certificate of Amendment to the Restated Certificate of Incorporation effective. |
| July 1, 2020 | Asset Purchase Agreement with UAB Caerus Biotechnologies. |
| July 2, 2020 | 8-K filing for Form of Wainwright Warrant. |
| December 8, 2020 | Certificate of Amendment to the Restated Certificate of Incorporation effective. |
| December 10, 2020 | Agreement and Plan of Merger with Neos Therapeutics, Inc. and Commitment Letter with Encina Business Credit, LLC. |
| March 19, 2021 | Consent, Waiver and Amendment No. 1 to Loan and Security Agreement with Encina Business Credit, LLC. |
| March 22, 2021 | Certificate of Amendment of Certificate of Incorporation effective. |
| March 22, 2021 | 8-K filing for Certificate of Amendment and Consent, Waiver and Amendment No. 1 to Loan and Security Agreement. |
| March 31, 2021 | Termination and Transition Agreement with Acerus Pharmaceuticals Corporation. |
| April 12, 2021 | Asset Purchase Agreement with Rumpus VEDS LLC, Rumpus Therapeutics LLC, Rumpus Vascular LLC, Christopher Brooke and Nathaniel Massari. |
| May 17, 2021 | 10-Q filing for Asset Purchase Agreement, Termination and Transition Agreement, Option Agreement, and Exclusive License Agreement. |
| June 29, 2021 | Termination Agreement with Avrio Genetics, LLC. |
| September 28, 2021 | 10-K filing for Asset Purchase Agreement and Termination Agreement. |
| January 26, 2022 | Consent, Joinder and Second Amendment to Loan and Security Agreement with Eclipse Business Capital LLC and Loan and Security Agreement with Avenue Capital Lenders. |
| February 14, 2022 | 10-Q filing for Consent, Joinder and Second Amendment to Loan and Security Agreement, Loan and Security Agreement, Registration Rights Agreement, and Form of Warrant. |
| March 4, 2022 | 8-K filing for Form of Prefunded Common Stock Purchase Warrant and Form of Common Stock Purchase Warrant. |
| May 9, 2022 | Amended and Restated Bylaws. |
| May 12, 2022 | Settlement and Termination of License Agreement with TRIS Pharma, Inc. |
| May 16, 2022 | 10-Q filing for Settlement and Termination of License Agreement. |
| July 1, 2022 | 8-K filing for Form of Indemnification Agreement. |
| August 10, 2022 | 8-K filing for Form of Prefunded Warrant and Form of Common Warrant. |
| September 27, 2022 | 10-K filing for Description of Securities. |
| January 4, 2023 | Certificate of Amendment of Certificate of Incorporation effective. |
| January 5, 2023 | 8-K filing for Certificate of Amendment of Certificate of Incorporation. |
| February 13, 2023 | Amended and Restated Employment Agreement with Joshua R. Disbrow. |
| March 20, 2023 | Amended and Restated Employment Agreement with Jarrett T. Disbrow. |
| March 21, 2023 | Amended and Restated Employment Agreement with Greg Pyszczymuka. |
| March 24, 2023 | Amendment No. 4 to Loan and Security Agreement with Eclipse Business Capital LLC and Second Amendment to Loan Documents with Avenue Capital Management II L.P. |
| May 11, 2023 | 10-Q filing for Amendment No. 4 to Loan and Security Agreement and Second Amendment to Loan Documents. |
| June 5, 2023 | S-1/A filing for Form of Prefunded Warrant, Form of Tranche A Warrant, Form of Placement Agency Agreement, and Form of Securities Purchase Agreement. |
| June 23, 2023 | S-8 filing for Aytu BioPharma, Inc. 2023 Equity Incentive Plan. |
| October 12, 2023 | 10-K filing for Commercial Lease Agreement and its amendments, Amended and Restated Employment Agreement with Joshua R. Disbrow and Greg Pyszczymuka. |
| November 13, 2023 | Commercial Manufacturing Services Agreement with Halo Pharmaceutical, Inc. |
| February 14, 2024 | 10-Q filing for Commercial Manufacturing Services Agreement. |
| June 12, 2024 | Consent, Joinder and Amendment No. 5 to Loan and Security Agreement with Eclipse Business Capital LLC, Term Loan Note, and Second Amended and Restated Revolving Note. |
| June 18, 2024 | 8-K filing for Consent, Joinder and Amendment No. 5 to Loan and Security Agreement, Term Loan Note, and Second Amended and Restated Revolving Note. |
| September 26, 2024 | 10-K filing for Certificate of Amendment to the Restated Certificate of Incorporation, List of Subsidiaries, and Amended and Restated Employment Agreement with Jarrett T. Disbrow. |
| November 11, 2024 | Amended and Restated Employment Agreement with Ryan J. Selhorn. |
| November 13, 2024 | 8-K filing for Amended and Restated Employment Agreement with Ryan J. Selhorn. |
| December 1, 2024 | Separation and Release Agreement with Mark K. Oki. |
| February 12, 2025 | 10-Q filing for Separation and Release Agreement. |
| May 21, 2025 | 8-K filing for Amendment to the Aytu BioPharma, Inc. 2023 Equity Incentive Plan. |
| June 2, 2025 | Previous S-1 filing with a total offering amount of $12,000,000. |
| June 5, 2025 | Current S-1/A filing date. |
Keywords
Aytu BioPharma, S-1/A, SEC Filing, Registration Statement, Common Stock, Prefunded Warrants, Capital Raise, Biopharma, Pharmaceuticals, Equity Offering, Filing Fees
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