SCHEDULE: Vanguard Discloses 5.31% Stake in Annexon Inc.

The Vanguard Group has reported a passive beneficial ownership of 5.31% in Annexon Inc., totaling 5,835,112 common shares.

Summary

• The Vanguard Group, an investment adviser, has filed a Schedule 13G indicating beneficial ownership in Annexon Inc.
• As of September 30, 2025, Vanguard beneficially owns 5,835,112 shares of Annexon Inc. Common Stock.
• This ownership represents 5.31% of Annexon Inc.'s outstanding common stock.
• Vanguard holds sole dispositive power over 5,198,664 shares and shared dispositive power over 636,448 shares.
• Vanguard holds no sole voting power but has shared voting power over 604,422 shares.
• The securities were acquired and are held in the ordinary course of business, not for the purpose of changing or influencing control of Annexon Inc.

Sentiment

Score: 5

Explanation: The filing is a neutral, factual disclosure of beneficial ownership by a large institutional investor, with no operational or financial updates that would typically influence sentiment.

Positives

• A major institutional investor like The Vanguard Group holding a significant stake can be seen as a vote of confidence in Annexon Inc.'s long-term prospects.
• The passive nature of the filing indicates that Vanguard is not seeking to influence management or control, suggesting a stable institutional holding.

Negatives

• No specific negative information is contained within this beneficial ownership report.

Future Outlook

This filing does not contain any forward-looking statements or guidance regarding Annexon Inc.'s future performance or operations.

Industry Context

This filing reflects a routine disclosure by a large asset manager, The Vanguard Group, regarding its passive investment in a publicly traded company, Annexon Inc. Such disclosures are common as institutional funds manage diversified portfolios and cross beneficial ownership thresholds.

Stakeholder Impact

• Shareholders: Provides transparency regarding a significant institutional holder, potentially reinforcing confidence in the stock's liquidity and institutional interest.
• Management: Awareness of a large, passive institutional investor on the shareholder register.

Key Dates

Keywords

Annexon Inc., Vanguard Group, Beneficial Ownership, Schedule 13G, Common Stock, Institutional Investor, ANXN