SCHEDULE: FMR LLC Discloses 7.1% Stake in Annexon Inc.
Beneficial Ownership Report
FMR LLC and Abigail P. Johnson have disclosed a 7.1% beneficial ownership stake in Annexon Inc. common stock as of December 31, 2025.
Summary
- FMR LLC, a parent holding company, and Abigail P. Johnson, an individual, jointly reported beneficial ownership of 10,222,470.36 shares of Annexon Inc. common stock.
- This aggregate amount represents 7.1% of the total outstanding common stock of Annexon Inc.
- FMR LLC holds sole voting power over 10,216,569.00 shares and sole dispositive power over 10,222,470.36 shares.
- Abigail P. Johnson, as a Director, Chairman, and CEO of FMR LLC, is deemed to beneficially own the same aggregate amount of shares (10,222,470.36) with sole dispositive power, but no sole or shared voting power directly.
- The securities were acquired and are held in the ordinary course of business, not for the purpose of changing or influencing control of Annexon Inc.
- The filing includes several FMR LLC subsidiaries and affiliates such as FIAM LLC, Fidelity Institutional Asset Management Trust Company, Fidelity Management & Research Company LLC, and Strategic Advisers LLC, which beneficially own shares.
Sentiment
Score: 7
Explanation: StockSavvy.ai views this filing as moderately positive. The disclosure of a significant stake by a reputable institutional investor like FMR LLC, along with its certification of holding shares in the ordinary course of business, generally signals investor confidence in Annexon Inc.
Positives
- A significant beneficial ownership stake (7.1%) by a major institutional investor like FMR LLC can signal confidence in Annexon Inc.'s long-term prospects.
- The disclosure indicates that the shares are held in the ordinary course of business, suggesting a passive investment rather than an activist intent to influence control.
Negatives
- This filing is a disclosure of ownership and does not inherently contain negative operational or financial information about Annexon Inc.
Risks
- This Schedule 13G filing primarily reports beneficial ownership and does not detail specific risks related to Annexon Inc.'s operations or financial health.
Future Outlook
This Schedule 13G filing is a disclosure of current beneficial ownership and does not contain forward-looking statements or guidance regarding Annexon Inc.'s future performance or outlook.
Industry Context
StockSavvy.ai notes that a significant stake by FMR LLC, a prominent asset management firm, in a biotechnology company like Annexon Inc. can be viewed positively by the market. Such institutional investments often reflect a belief in the company's underlying science, pipeline, or market potential, aligning with broader trends of institutional capital flowing into innovative biotech firms.
Comparison to Industry Standards
- StockSavvy.ai observes that a 7.1% stake is a substantial position for an institutional investor in a publicly traded company, indicating a high conviction investment. For comparison, similar significant stakes by large asset managers like BlackRock or Vanguard in other biotech companies often range from 5% to 10%, reflecting their long-term investment strategies rather than short-term trading.
Corporate Governance
| Change Type | Description | Effective Date | Impact Assessment |
|---|---|---|---|
| Ownership Disclosure | FMR LLC and Abigail P. Johnson disclosed a 7.1% beneficial ownership stake in Annexon Inc. common stock. | 2025-12-31 | This disclosure provides transparency regarding a significant institutional shareholder's position, which is a standard corporate governance requirement. It confirms that the shares are held for investment purposes and not to influence control, which generally indicates stability in the shareholder base. |
Stakeholder Impact
- Shareholders: The disclosure of a significant institutional stake by FMR LLC may instill confidence among existing shareholders and potentially attract new investors, as it suggests a vote of confidence from a major financial entity.
- Management: Management may view this as validation of their strategy and operations, knowing a large, reputable investor holds a substantial position without seeking to influence control.
Key Dates
| Date | Description |
|---|---|
| 2023-01-03 | Effective date of Power of Attorney for FMR LLC and its direct and indirect subsidiaries. |
| 2023-01-26 | Effective date of Power of Attorney for Abigail P. Johnson. |
| 2025-12-31 | Date of event which requires filing of this statement, representing the beneficial ownership reporting date. |
| 2026-02-04 | Signature date of the Schedule 13G filing and the date of the Rule 13d-1(k)(1) agreement for joint filing. |
Recommendation
holdA Schedule 13G filing primarily reports beneficial ownership and does not provide sufficient operational or financial details to warrant a 'buy' or 'sell' recommendation. However, the disclosure of a significant 7.1% stake by a major institutional investor like FMR LLC is generally a positive signal, suggesting confidence in the company. Therefore, a 'hold' recommendation is appropriate, acknowledging the positive signal without implying a change in the company's fundamental outlook based solely on this ownership report.
Keywords
Annexon Inc., FMR LLC, Abigail P. Johnson, Beneficial Ownership, Common Stock, Institutional Investor, SEC Filing, ANXN, Fidelity
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