SCHEDULE: FMR LLC Boosts Annexon Stake to 14.3%

FMR LLC and Abigail P. Johnson report a 14.3% beneficial ownership stake in Annexon Inc. common stock as of June 30, 2025.

Summary

• FMR LLC and Abigail P. Johnson have filed an Amendment No. 3 to Schedule 13G, reporting their beneficial ownership in Annexon Inc.'s common stock.
• As of June 30, 2025, FMR LLC and Abigail P. Johnson collectively beneficially own 15,695,226.36 shares of Annexon Inc. common stock.
• This aggregate amount represents 14.3% of the total outstanding common stock of Annexon Inc.
• FMR LLC holds sole voting power over 15,690,765.00 shares and sole dispositive power over 15,695,226.36 shares.
• Abigail P. Johnson, as a Director, Chairman, and CEO of FMR LLC, is deemed to beneficially own the same shares as FMR LLC.
• The securities were acquired and are held in the ordinary course of business and not for the purpose of changing or influencing the control of Annexon Inc.

Sentiment

Score: 6

Explanation: The filing is a factual report of beneficial ownership. While it doesn't contain operational news, a significant stake by a reputable institutional investor like FMR LLC can be perceived as a positive signal of confidence in the issuer, hence a slightly positive score.

Positives

• A significant 14.3% ownership stake by a major institutional investor like FMR LLC can signal confidence in Annexon Inc.'s long-term prospects.
• The filing indicates that the shares are held in the ordinary course of business, suggesting a passive investment rather than an activist stance, which can provide stability.

Future Outlook

NA

Industry Context

NA

Related Party Transactions

• Abigail P. Johnson is identified as a Director, Chairman, and Chief Executive Officer of FMR LLC.
• Members of the Johnson family, including Abigail P. Johnson, are the predominant owners of Series B voting common shares of FMR LLC, representing 49% of its voting power.
• The Johnson family group and other Series B shareholders have a voting agreement to vote all Series B shares in accordance with the majority vote, potentially forming a controlling group with respect to FMR LLC under the Investment Company Act of 1940.

Stakeholder Impact

• Shareholders may view the significant and continued investment by FMR LLC as a vote of confidence in Annexon Inc., potentially leading to increased investor interest.

Key Dates

Keywords

Annexon Inc, FMR LLC, Abigail P. Johnson, Beneficial Ownership, Schedule 13G, Common Stock, Institutional Investor