Form 4: Foresite Capital Boosts ALUMIS Stake with Major Purchases

Foresite Capital entities, including a 10% owner and director, reported significant purchases of ALUMIS INC. common stock totaling over 500,000 shares across multiple transactions in November 2025.

Summary

• Foresite Capital Management VI LLC and several affiliated entities, identified as a 10% owner and director of ALUMIS INC. (ALMS), reported multiple purchases of common stock.
• On November 17, 2025, 50,000 shares were acquired at $5.60 per share, and an additional 150,000 shares were purchased at $5.59 per share.
• On November 18, 2025, 117,374 shares were acquired at $6.19 per share.
• On November 19, 2025, 190,500 shares were purchased at $6.56 per share.
• These transactions collectively represent the acquisition of 507,874 shares of ALUMIS INC. common stock by Foresite Capital entities.
• Following these reported transactions, the various Foresite Capital entities beneficially own a combined total of 15,705,828 shares of ALUMIS INC. common stock.
• The shares are held indirectly through various funds and co-invest vehicles managed by Foresite Capital, with James B. Tananbaum identified as having sole or shared voting and dispositive power over these shares.

Sentiment

Score: 8

Explanation: The significant insider buying by a major institutional investor and director indicates strong positive sentiment and conviction in the company's value and future performance.

Positives

• Significant insider buying by a 10% owner and director, Foresite Capital, signals strong confidence in ALUMIS INC.'s future prospects and valuation.
• The acquisition of over half a million shares across several days demonstrates a sustained belief in the company by a major institutional investor.

Future Outlook

NA

Industry Context

NA

Related Party Transactions

• Foresite Capital entities, which include a 10% owner and director of ALUMIS INC., purchased common stock from the open market. These transactions are considered related party dealings due to the reporting persons' significant influence and board representation.

Stakeholder Impact

• Shareholders may view the significant insider purchases as a positive signal, potentially increasing investor confidence and demand for the stock.

Key Dates

Recommendation

The substantial purchases of ALUMIS INC. common stock by Foresite Capital entities, who are both a 10% owner and have director representation, indicate strong conviction in the company's valuation and future performance. This insider buying activity, totaling over half a million shares, suggests that informed parties believe the stock is undervalued or poised for growth, making it a compelling 'buy' signal for investors.

Keywords

ALUMIS INC, ALMS, Foresite Capital, insider buying, stock purchase, beneficial ownership, 10% owner, director, institutional investment