Form 4: Foresite Capital Boosts ALUMIS Stake

Foresite Capital Management VI LLC and related entities reported the purchase of 72,212 shares of ALUMIS INC. common stock at $7.38 per share, increasing their beneficial ownership.

Summary

• Foresite Capital Management VI LLC, acting as a 10% owner and through related entities, reported an acquisition of ALUMIS INC. common stock.
• On November 21, 2025, 72,212 shares of common stock were purchased at a price of $7.38 per share.
• The transaction was made pursuant to a Rule 10b5-1 plan.
• Following this transaction, the various Foresite Capital entities collectively beneficially own 15,778,040 shares of ALUMIS INC. common stock.
• Specifically, Foresite Capital Opportunity Fund V, L.P. holds 2,614,215 shares, Foresite Capital Fund VI, L.P. holds 4,247,670 shares, Foresite Capital Fund V, L.P. holds 5,584,889 shares, Labs Co-Invest V, LLC holds 194,459 shares, Foresite Labs Fund I, L.P. holds 1,960,337 shares, and Foresite Labs Affiliates 2021, LLC holds 1,176,470 shares.
• James B. Tananbaum, as managing member of several Foresite entities, may be deemed to have voting and dispositive power over these shares.

Sentiment

Score: 8

Explanation: The purchase of additional shares by a significant institutional investor and 10% owner, especially under a 10b5-1 plan, is a strong positive signal of confidence in the company's future value and prospects.

Positives

• A significant institutional investor and 10% owner, Foresite Capital, increased its stake in ALUMIS INC.
• The purchase was made at $7.38 per share, indicating confidence in the company's valuation at that price point.
• The transaction was executed under a Rule 10b5-1 plan, suggesting a pre-planned investment strategy.

Future Outlook

The filing does not contain any explicit forward-looking statements or guidance regarding ALUMIS INC.'s future performance or strategic direction.

Industry Context

An increase in stake by a significant institutional investor like Foresite Capital, particularly one with a director relationship, can signal confidence in ALUMIS INC.'s prospects within its industry. This type of insider buying often attracts positive attention from other investors, suggesting potential undervaluation or strong future growth expectations.

Comparison to Industry Standards

• This Form 4 reports an insider purchase, which is a specific transaction type and does not lend itself to direct comparison with industry-wide operational or financial benchmarks.
• However, insider buying by a 10% owner and director is generally viewed favorably, similar to how institutional investors like BlackRock or Vanguard increasing their positions in a sector peer might be interpreted as a vote of confidence.

Related Party Transactions

• Foresite Capital Management VI LLC and its related entities, which include a director and 10% owner of ALUMIS INC., engaged in a purchase of common stock. This constitutes an insider transaction.

Stakeholder Impact

• Shareholders: The purchase by a significant institutional investor and director may be perceived as a positive signal, potentially boosting investor confidence and share price.
• Employees, Customers, Suppliers, Creditors: No direct impact is indicated by this specific filing, though increased investor confidence could indirectly benefit the company's overall stability and growth prospects.

Key Dates

Recommendation

The purchase of additional shares by a major institutional investor and 10% owner, Foresite Capital, at a specific price point, signals strong insider confidence in ALUMIS INC.'s valuation and future prospects. This type of insider buying, especially when executed under a Rule 10b5-1 plan, often precedes positive developments or indicates a belief that the stock is undervalued. For a seasoned investor, this action suggests a favorable outlook and could warrant a 'buy' recommendation.

Keywords

ALUMIS INC., ALMS, Foresite Capital, Insider Buying, Stock Purchase, Beneficial Ownership, SEC Form 4, Institutional Investment, Rule 10b5-1