SCHEDULE: Opaleye Management Discloses 9.52% Stake in Alpha Cognition

Opaleye Management Inc. and affiliates reported a 9.52% beneficial ownership stake in Alpha Cognition Inc. as of December 31, 2025.

Summary

• Opaleye Management Inc., Opaleye, L.P., and James Silverman collectively reported beneficial ownership of 2,070,784 shares of Alpha Cognition Inc. Common Stock.
• This aggregate amount represents 9.52% of Alpha Cognition Inc.'s outstanding common shares.
• The percentage is calculated based on 21,742,104 Common Shares outstanding, as reported by Alpha Cognition, Inc. in its Form 10-Q filed on November 13, 2025.
• Opaleye Management Inc. and James Silverman each reported shared voting and dispositive power over 2,070,784 shares.
• Opaleye, L.P. reported shared voting and dispositive power over 2,015,784 shares, representing 9.27% of the class.
• The reporting persons certified that the securities were not acquired and are not held for the purpose of changing or influencing control of the issuer.

Sentiment

Score: 7

Explanation: StockSavvy.ai views this as a moderately positive development, as a significant institutional stake typically reflects investor confidence in the company's prospects, although the filing itself is purely a disclosure of ownership.

Positives

• A significant institutional investor, Opaleye Management Inc. and its affiliates, has disclosed a substantial stake of 9.52% in Alpha Cognition Inc., indicating potential confidence in the company's future.

Future Outlook

NA

Industry Context

StockSavvy.ai notes that the disclosure of a significant stake by an institutional investment adviser like Opaleye Management Inc. in a company such as Alpha Cognition Inc. often signals a vote of confidence in the company's strategic direction or potential, which can be a positive indicator for the broader market, particularly within the biotechnology sector where such investments are closely watched.

Stakeholder Impact

• Shareholders may view the significant institutional ownership as a positive signal, potentially increasing investor confidence and interest in Alpha Cognition Inc.

Key Dates

Recommendation

The filing indicates a significant institutional stake by Opaleye Management Inc. and its affiliates, which can be interpreted as a vote of confidence in Alpha Cognition Inc. While this is a positive signal, the filing itself does not provide performance metrics or strategic updates to warrant a stronger recommendation. Investors should hold and monitor for further developments.

Keywords

Alpha Cognition, Opaleye Management, Beneficial Ownership, Schedule 13G, Institutional Investor, Common Stock, Biotechnology