SCHEDULE 13G: Opaleye Management Discloses 8.97% Stake in Alpha Cognition

Opaleye Management Inc., Opaleye, L.P., and James Silverman have reported a collective beneficial ownership of 8.97% in Alpha Cognition Inc.'s common stock.

Summary

• Opaleye Management Inc., Opaleye, L.P., and James Silverman collectively reported beneficial ownership of 1,875,142 shares of Alpha Cognition Inc. Common Stock.
• This ownership represents 8.97% of Alpha Cognition Inc.'s outstanding common shares, based on 20,902,104 shares outstanding as reported by the company on October 1, 2025.
• The reporting persons share both voting and dispositive power over all 1,875,142 shares.
• The filing explicitly states that the securities were not acquired and are not held for the purpose of changing or influencing the control of Alpha Cognition Inc.

Sentiment

Score: 6

Explanation: The filing is a routine disclosure of a significant passive stake by an institutional investor, which can be viewed as a mild positive signal of confidence in the issuer, Alpha Cognition Inc.

Positives

• A significant institutional investor, Opaleye Management Inc., has disclosed an almost 9% passive stake in Alpha Cognition Inc., which may be interpreted as a vote of confidence in the company's prospects.

Risks

• The filing certifies that the securities were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer, mitigating potential risks associated with activist investor intentions.

Future Outlook

This filing does not contain any forward-looking statements or guidance regarding Alpha Cognition Inc.'s future performance or operations.

Management Comments

• James Silverman, President of Opaleye Management Inc. and General Partner of Opaleye, L.P., certified that the information set forth in the statement is true, complete, and correct to the best of his knowledge and belief.

Industry Context

This filing is a routine disclosure of a significant ownership stake by an institutional investor and does not provide specific insights into broader industry trends or competitive landscape for Alpha Cognition Inc.

Stakeholder Impact

• Shareholders: Provides transparency regarding a significant institutional holder's stake, which can influence market perception and potentially share price.

Key Dates

Keywords

Alpha Cognition Inc., Opaleye Management Inc., Opaleye L.P., James Silverman, Beneficial Ownership, SEC Filing, Schedule 13G, Common Stock, Institutional Investor, Equity Stake